Knockout mouse (VASP-/-, Mena-/-, VASP-/-/Mena-/-)를 이용하여 암의 전이과정에서 일어나는 혈관신생(angiogenesis) 연구
악성 흑색종 세포주 B16F10을 이용한 VASP 및 AMPK 단백질의 특성 규명
siRNA를 통하여 암조직의 혈관신생을 억제할 수 있는 신약 개발 연구
연구결과
Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cell. (2007) Ann NY Acad Sci 1095: 496-503
Apoptotic effect of EGCG in HT-29 colon cancer cells via AMPK signal pathway. (2007) Cancer Letters 247: 115-121
Reseveratrol induces apoptosis in chemo-resistant cancer cells via modulation of AMPK signaling pathway. (2007) Ann NY Acad Sci 1095: 441-448
Possible link between NO concentration and COX-2 expression in systems treated with soy-isoflavones. (2007) Ann NY Acad Sci 1095: 564-573
Differential modulation of AMPK signaling pathways by low or high levels of exogenous reactive oxygen species in colon cancer cell. (2007). Ann NY Acad Sci 1091: 102-109
Selenium regulates COX-2 and ERK signaling pathways by activating AMPK in colon cancer cells. (2006) Cancer Research 66(20): 10057-10063
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